摘要：聚酰胺-胺（PAMAM）树枝状大分子是一种具有结构规整、高度支化、高表面官能团密度等特点的高分子聚合物。由于其分子量、尺寸和表面官能团等高度可控，使得PAMAM树枝状大分子广泛应用于催化剂、表面活性剂、药物缓释等方面。37769
本文以乙二胺、丙烯酸甲酯为原料，通过重复的Michael加成反应和酰胺化反应制备各代PAMAM树枝状大分子，并对其合成条件（原料配比、反应温度、反应时间及合成环境）进行优化，得到最佳合成条件：合成半代PAMAM树枝状大分子时，原料配比为1:8，35°C、氮气保护下反应24h；合成整代PAMAM树枝状大分子时，原料配比为1:24，25°C、氮气保护下反应24h。
本文通过FTIR、1H-NMR对PAMAM树枝状大分子的结构进行表征，并测定其粘度、溶解性等性能。
毕业论文关键词：聚酰胺-胺；树枝状大分子；Michael加成反应；酰胺化反应；发散法
Synthesis and Characterization of PAMAM
dendrimers
Abstract:PAMAM dendrimers is a new type of polymer, which is characterized by its orderly structure, highly branched and a large number of functional groups and so on. Therefore, during the process we can precisely control the molecular weight, molecular size and surface functional groups of PAMAM dendrimer, so that it can be widely used in catalyst,surfactant, drug realease, etc.
It is synthesized by circular Machel addition reaction and amidation reaction with ethylenediamine(EDA) as core based on the principle of step-growth polymerization. and optimized the reaction conditions(reaction temperature and time, feed ratios and reaction condition) . The best reaction conditions of synthesis half generation of PAMAM are feed ratio is 1: 8, 35°C, 24 h and nitrogen protection. The best reaction conditions of synthesis entire generation of PAMAM are feed ratio is 1: 24, 25°C, 24 h and nitrogen protection.
Then, FTIR, 1H-NMRwas used to characterize the structure of dendrimers, and viscosity analyzer, solubility was used to characterized the performance.
KeyWords: Polyamidoamine; Dendrimers; Michael addition reaction; Amination reaction; Divergent
目录
1 绪论 1
1.1 树枝状大分子简介 1
1.1.1 树枝状大分子的结构 1
1.1.2 树枝状大分子的特性 2
1.1.3 树枝状大分子的种类 3
1.2 树枝状大分子的合成方法 4
1.3 PAMAM树枝状大分子的应用 5
1.3.1 表面活性剂 6
1.3.2 催化剂载体 6
1.3.3 药物缓释 6
1.3.4 自组装 6
1.3.5 造影剂 7
1.3.6 纳米材料模板 7
1.4 现有问题 7
1.5 选题依据 7
1.6 立题目的和意义 7
1.7 研究内容和目标 8
1.7.1 研究内容 8
1.7.2 研究目标 8
1.8 创新性 8
2 实验部分 9
2.1 原料与仪器 9
2.2 实验原理 9
2.3 实验方案 10
2.3.1 原料的纯化 10
2.3.2 PAMAM树枝状大分子的制备 10
2.3.3 反应条件的优化 11
2.4 表征方法 12
2.4.1 FTIR分析 12
2.4.2 溶解性分析 12
2.4.3 1H-NMR分析 13
2.4.4 粘度分析 13
2.4.5 元素分析 14
2.4.6 应用评价 14
3 结果与讨论 16
3.1 FTIR分析 16 PAMAM树枝状大分子的设计合成与表征:http://www.751com.cn/cailiao/lunwen_36616.html