摘要: 本论文主要设计合成具有新颖结构和性质的多金属氧酸盐，以Anderson型杂多酸为切入点，在多酸上引入功能化的有机基团。通过Tris-NH2修饰的Al-Anderson型杂多酸与(R)-1-(1-苯乙基)异硫氰酸酯合成(R)-1-(1-苯乙基)硫脲修饰的Al-Anderson型杂多酸催化剂的反应。该方法将硫脲小分子单侧共价修饰到Al-Anderson型杂多酸上，使得小分子的酸性增强，催化剂的活性提高，从而减少催化剂的用量。另外，我们还研究了Tris-NH2修饰的多酸为催化剂催化苄胺生成亚胺的反应。本研究不仅丰富了多金属氧酸盐的结构，而且扩大了多酸的应用范围。58152

毕业论文关键词：杂多酸；单侧修饰；硫脲；催化

Design and Synthesis of  (R) -1- (1-phenylethyl) thiourea modified Al-Anderson-type heteropoly acid catalyst

Abstract: A novel approach for the design and synthesis of polyoxometalates has been developed in this thesis, functional groups are introduced into the Anderson-type heteropolyacid which was as the starting point. The synthesis of (R)-1-(1-phenylethyl) thiourea modified Al-Anderson-type heteropoly catalyst by Tris-NH2-modified Al-Anderson-type heteropolyacid and (R) -1- (1- phenylethyl) isothiocyanate. Thiourea molecules was modified in the one side of Al-Anderson-type heteropolyacid by the covalent modification that enhanced the acid of small molecule and improved the activity of the catalyst, thereby reducing the catalyst dosage. In addition, we also studied the reaction Tris-NH2 modified acid as Catalyst benzylamine generated imine. This study not only enriches the structure of the multi metal oxide, but also expands the application range of polyoxometalates.

Key Words: Heteropolyacids；Single-Side modification；Thiourea；Catalytic

目录

1 绪论 1

1.1 课题背景和意义 1

1.2 多金属氧酸盐的简介 2

1.2.1 多金属氧酸盐定义 2

1.2.2 多金属氧酸盐的发展简史 2

1.2.3多金属氧酸盐的分类 3

1.3 多金属氧酸盐催化剂的优秀特性 5

1.4 多金属氧酸盐的药物化学特性 6

1.5 Anderson多酸的研究现状 7

1.6 多酸的共价修饰 10

1.7 硫脲催化剂的制备与发展 11

1.7.1 硫脲合成的发展 11

1.7.2 异硫氰酸酯合成的发展 12

1.8 小结 13

2 实验部分 14

2.1试剂与仪器 14

2.1.1 试剂 14

2.1.2 实验仪器 15

2.2 实验内容 15

2.2.1 实验总体路线 15

2.2.2 Al-Anderson型杂多酸母体Na3[Al(OH)6Mo6O18]的制备 15

2.2.3 Al-Anderson型杂多酸母体(NH4)3[Al(OH)6Mo6O18]的制备步骤 16

2.2.4 (R)-1-(1-苯乙基)异硫氰酸酯的制备 16

2.2.5 单侧氨基修饰的Al-Anderson型多金属氧酸盐的制备 16

3 结果与讨论 17

3.1 结果 17

3.1.1 Al-Anderson型杂多酸母体Na3[Al(OH)6Mo6O18]的制备 (R)- 1-（1-苯乙基）硫脲修饰的Al-Anderson型杂多酸催化剂的设计与合成:http://www.751com.cn/huaxue/lunwen_63120.html