摘要含氮的杂环化合物因为其有着独特的生物活性,内吸性高，毒性又很低等的特点，所以常被应用于医药和农药这些方面。在这些含氮的杂环化合物中，含吡咯烷基类的杂环化合物是催化Michael加成反应和羟醛缩合反应的一个良好的有机催化剂。L-脯氨酸及其衍生物是其中的一种有机小分子催化剂, 它在许多重要有机反应中取得了非常好的催化效果。但据我们所知，在均相反应中，虽然催化剂能够很好的催化反应，但这些催化剂却不易回收和利用，因此非均相催化应运而生。通过将吡咯烷侧基引进刚性的羧酸分子中，使得其成为一个含吡咯烷侧基的刚性羧酸配合物。通过配体中的孔径可以更好的催化反应，也可以很好的回收和重复利用。本文采用BOC保护的L-脯氨酸和刚性的三联苯二甲酸反应来得到含吡咯烷侧基的刚性羧酸配体，通过和合适金属配位来得到目标配体，并对其结构进行表征。47428
Abstract：Nitrogen containing heterocyclic compound because of its unique biological activity, high absorption characteristics, and very low toxicity, so it is often used in medicine and pesticide in these areas. In these nitrogen heterocyclic compounds, heterocyclic compounds containing pyrrolidine base is a good organic catalytic in Michael addition reaction and aldol condensation reaction. L- proline and its derivatives are a kind of organic small molecules in the catalyst, its catalytic effect is very good in many important organic reactions. But as far as we know, in the homogeneous reaction, while the reaction can be the very good catalyst, the catalyst is difficult to recycle, so the heterogeneous catalytic emerge as the times require. Through the introduction of pyrrolidine to the rigid carboxylic complexes. it has contained pyrrolidine side groups. The catalytic reaction through the aperture in the ligand can be better, but also can be easily recovered and reused. Rigid carboxylic ligands terphenyl two formic acid reaction using BOC protected L- proline and rigid to pyrrolidine containing side groups, and through appropriate metal coordination to get the target ligands, and their structures were characterized..
毕业论文关键词：吡咯烷基; 二甲基-2,2'-氨基-1,1':4,1'-三联苯-4,4'二羧酸; 合成
Keyword: pyrrolidinyl; dimethyl 2'-amino1,1':4,1''-terphenyl-4,4''-dicarboxylate;
目 录
1.前言 1
1.1研究背景 1
1.2研究现状 1
1.3研究意义 8
2.实验部分 9
2.1实验仪器 9
2.2实验试剂 9
2.3配体合成 10
2.3.1二甲基-2,2'-氨基-1,1':4,1'-三联苯-4,4'二甲酸的合成 10
2.3.2二甲基-2,2'-氨基-1,1':4,1'-三联苯-4,4'二甲酸的结构表征 10
2.3.3二甲基-2-(1-(叔丁氧基羰基)-吡咯烷-2-甲酰胺基)-三联苯4,4'-二甲酸的 合成 11
2.3.4二甲基-2-(1-(叔丁氧基羰基)-吡咯烷-2-甲酰胺基)-三联苯4,4'-二甲酸结构的表征...........................................................11.
2.3.5配合物的合成.............................................12
2.3.6配合物的表征...............................................12
3.结果与讨论 13
参考文献 14
致 谢 含吡咯烷侧基刚性羧酸配合物的合成及表征:http://www.751com.cn/huaxue/lunwen_49529.html